(P-122) An Evidence-based Evaluation of Clinical Medicine Use Indicators in Children

Background: China' government has issued a policy stating that a comprehensive clinical evaluation system for children's medication should be established.

Objectives: To analyze and evaluate the present status of evaluation index of clinical rational drug use worldwide, so that to provide references to establish the pediatric clinical medicine evaluation system.

Methods: Databases including Pubmed, Embase, CBM、VIP、CNKI and international health relative official websites such as WHO and EMA and 16 representative national health administrative department from five continent were searched to collect evaluation Index of clinical drug use from inception to July 2018. Two reviewers independently screened literature, extracted data including basic characteristics, content of evaluation index of clinical drug use and assessment content. Then a descriptive analysis was conducted.

Results: We included 15 relative literature, 3 came from WHO,1 came from German which is consistent with EMA, 4 came from America, and Canada, South Africa, Australia each have developed an evaluation index of clinical rational drug use and 5 came from China. All included literature referred the evaluation index of clinical rational drug use, and all the evaluation index covered safety, effectiveness, cost, suitability of dosage form, and suitability of strength. The evaluation index came from WHO、Canada, South Africa, Australia and China especially referred the accessibility should be taken into account in the process of drug evaluation. The Evaluation index came from WHO, South Africa and China indicate the unilateral preparation priority and compound preparation supplement. The evaluation index came from WHO, EMA, America and China show clearly that should consider the significance of drug and people. Besides, South Africa and Australia pointed out the reliability of drug manufacture, as an important factor, should be paid attention to.

Conclusions: The Chinese government pay high attention to pediatric rational and smart drug use, therefore, we suggest that we should establish an special evaluation index for pediatric drug use according to the existing evaluation index of adult, so that to provide theoretical reference to guide the smart drug use in clinical, and eventually establish an comprehensive evaluation system for pediatric drug use.