(P-488) Estimates of Paracetamol Poisoning in Brazil: Analysis of Official Records

Background: Paracetamol related poisoning are researched in several countries. Despite the high consumption of paracetamol, Brazil lacks analyses paracetamol poisoning.

Objectives: To describe paracetamol poisoning in Brazil.

Methods: A cross section study of official records’ paracetamol poisoning, available from 1996 to 2018 in the Mortality Information System (SIM), Hospital Information System (SIH) and Notifiable Diseases Information System (SINAN). In SIM and SIH, records with codes F55, T39, X40, X60 and Y10 of ICD-10 were included. At SINAN, all commercial and discontinued paracetamol products were identified and recoded. Possible spelling errors were identified when checking products. The records were stratified according to age, sex and intentionality. From the annual data and by federation state, the mean and standard error of paracetamol poisoning in each stratum was calculated. The SIM, SIH and SINAN cases per 100,000 inhabitants were calculated by municipality and region and compared to the national average.

Results: 409 records were identified in SIM, 4,961 in SIH and 3,831 in SINAN. Deaths were more frequent in adults (71.3% ± 0.03), men (51.6% ± 0.03) and in suicide attempts (36.5% ± 0.03). Hospitalizations were more frequent among adults (69.1% ± 0.02), women (55.7% ± 0.03) and unintentional motivation (78.2% ± 0.05). Notifications of poisoning were more frequent in adults (67.6% ± 2.4), women (75.2% ± 2.1) due to unintended causes (68.8% ± 3.5). The most frequent regions were the South (102%) and the Southeast (15%) with results above the national average.

Conclusions: Economically active people suffered more intoxications. The results demonstrate that men and suicide attempts have had greater lethality in recent decades.