(P-420) The Prevalence and Associated Risk Factors of Perfumes Sensitivity in Saudi Arabia

Background: Several fragrance substances used in perfuming are well-established contact allergens and have been attributed to various health reactions. The prevalence and nature of sensitivity reactions caused by perfumes have not been thoroughly investigated.

Objectives: To identify the prevalence and associated risk factors of self-reported perfumes sensitivity among the general population in Saudi Arabia.

Methods: A cross-sectional study was conducted among adults aged ≥ 18 years between in October 2020. A survey was developed to assess socio-demographics, past medical history, perfumes buying behaviors, and detailed history of perfumes sensitivity. Significant associated risk factors of perfumes sensitivity were explored using multivariate regression analysis.

Results: A total of 1078 participants completed the survey with a mean age of 36.7 years (SD ± 10.36). The prevalence of perfumes sensitivity was self-reported in 14.6% of participants. Respiratory and skin symptoms were the most reported reactions with total rates of 40.1% and 35.7%, respectively. Moderate/Severe reaction was identified in 17.8% of participants. The most-reported perfume type attributed to perfumes sensitivity was Parfum (47.8%), and most of the reported perfume products were either unknown or counterfeits products (43.3%). History of asthma (OR= 3.2, 95%CI 1.88 – 4.37, p < 0.001) and the use of unknown/counterfeit perfume products (OR= 1.9, 95%CI 1.23–2.94, p < 0.003) were significantly associated with a higher risk of perfumes sensitivity.

Conclusions: The findings of this study showed that perfumes sensitivity is quite frequent experience among adults in Saudi Arabia. Taking into account the enormous perfumes market volume, further quantitative studies to determine the presence of fragrance allergens in perfumes are recommended. Furthermore, public awareness of the importance of perfumes authenticity is highly needed.