(P-407) Health Economics Analysis and Quality of Life of Patients Undergoing Primary Total Knee Arthroplasty (TKA) from China ATTUNE® Study

Background: Very limited data is available for the patient health related quality of life (HRQOL) and health economics outcomes of ATTUNE system in China.

Objectives: This interim analysis aimed to describe the cost of hospitalization, length of stay (LOS) and quality of life (QoL, measured by EQ5D and KOOS QoL domain) among Chinese patients who received the ATTUNE® Knee system in primary TKA in China ATTUNE® study (NCT03542045)..

Methods: China ATTUNE study® is a prospective, single arm, non-randomized, 4-center clinical study among Chinese patients with primary TKA. The cut-off date of the dataset was December 3rd, 2021 when eligible patients have been followed up for at least one year. Descriptive analysis was performed on the in-patient total health resource utilization in RMB, LOS in days. A multivariable was performed to compare repeated measurements of EQ5D-5L and KOOS QOL domain at baseline and post-operative follow-up period.

Results: At cut-off date, a total of 120 patients were enrolled, out of which 117 eligible patients (16.2% male; age: 63.3 ± 6.75 years) were included in this analysis with average 7.07 (1.11-17.48) month follow-up time. The total cost of hospitalization was ¥89,352.99 ± 24,486.01. The average cost of medication, procedure service, implant, disposables, examination and other medical cost was ¥5,543.37±2881.95, ¥7,211.9 ± 1758.1, ¥66,495.3 ± 21,475.9, ¥2,692.2 ± 1,490.9, ¥5,422.8 ± 2,004.72, ¥3,499.6 ± 2,168.8 respectively. The average LOS was 9.2 (± 2.98) days. Compared to pre-op baseline (0.50 ± 0.17), significant improvement was observed in EQ5D-5L index at 6 week (0.61 ± 0.15), 6 month (0.70 ± 0.13) and 1 year (0.79 ± 0.15) (p < 0.001). Patients reported better self-rated health status measured by EQ-VAS during follow-up period (76.5 ± 15.28 at week 6, 81.8 ± 12.16 at 6 month, and 86.6 ± 11.43 at 1 year) than pre-op baseline (67.3 ± 20.83) (P <0.0001). Significantly better scores in the KOOS QOL domain were observed during follow up period than at baseline.

Conclusions: This analysis result provided real-world information on the cost during hospitalization, LOS and QoL of patients with primary TKA. Compared to the existing clinical pathway issued by The National Health Commission of the People's Republic of China on average LOS of TKA (14-20 days), ATTUNE® Knee system could provide an opportunity for hospitals in optimizing TKA healthcare burden, with shortening hospital LOS and reducing related hospitalization cost while significantly improving long-term QoL of patients.