(P-360) Monitoring of Adverse Drug Reaction-related Parameters in Children, Youth and Young Adults Prescribed Antipsychotic Drugs by General Practitioners

Location: Poster Gallery-Pediatric Pharmacoepidemiology

Presenting Author(s)

LM

Lenneke Minjon

Utrecht University
Utrecht, Utrecht, Netherlands

Co-Author(s)

Ev

Els van den Ban

Karakter Child and Adolescent Psychiatry, Zwolle, the Netherlands, Netherlands
MB

Marloes T. Bazelier

Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands, Netherlands
AL

Arief Lalmohamed

Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht, the Netherlands, Netherlands
TE

Toine C.G. Egberts

Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands, Netherlands
EH

Eibert R. Heerdink

Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands, Netherlands

Background: Antipsychotic drugs can cause severe adverse drug reactions (ADRs), which makes the monitoring of children treated with these drugs important.

Objectives: To assess monitoring of ADR-related parameters in children, youth and young adults treated with second-generation antipsychotic drugs (SGAs) prescribed by general practitioners (GPs).

Methods: This retrospective follow-up study included children, youth and young adults aged 0-24 years who had an initial prescription of an SGA recorded in the Clinical Practice Research Datalink between 2000−2017, and who were prescribed an SGA more than once for a duration of at least six months. It was assessed which ADR-related physical parameters (weight, height, body mass index, waist circumference, pulse, blood pressure, and heart examination) and laboratory parameters (glucose, HbA1c, lipids, and prolactin) were monitored in children, youth and young adults at least once every six month period, stratified by sex, age categories, and calendar years. Relative risks (RRs) and 95% confidence intervals (95% CIs) were calculated.

Results: In total, 7,006 patients were included and the mean duration of follow-up was 1.6 years. Monitoring frequencies of all parameters were below 25%. Blood pressure and weight were monitored in 23.6% and 23.4%, respectively, of all children, youth and young adults during the first half-year; waist circumference was monitored in 0.2%. Females were monitored more often than males, some differences between age categories were observed, and monitoring frequencies increased after 2000, but did not exceed 35% in any year.

Conclusions: Monitoring frequencies of ADR-related parameters in children, youth and young adults treated with SGAs prescribed by a GP were low. Monitoring in primary care should be improved to enable a better evaluation of the benefit-risk balance during antipsychotic drug therapy.