(P-088) Association of Inflammatory Bowel Disease with the Risk of Parkinson’s Disease: A Meta-analysis of Real-world Evidence

Location: Poster Gallery-Health Economics/Outcomes Research

Presenting Author(s)

Salman Hussain

PhD Scholar
Department of Pharmaceutical Medicine, Jamia Hamdard, New Delhi, India, Delhi, India

Co-Author(s)

AN

Abul Kalam Najmi

Professor
Jamia Hamdard, India

Background: Recent epidemiological studies found a high risk of Parkinson’s disease (PD) in patients with inflammatory bowel disease (IBD). However, there are studies that found little or no risk of PD in patients with IBD. It remains controversial whether IBD enhances the risk of PD.

Objectives: The aim of this study was to compute the risk of PD associated with the presence of IBD

Methods: An extensive literature search was performed in PubMed, Embase, and Cochrane central from inception to December 2020. We included all the studies assessing the incidence or diagnosis of PD in IBD patients. Data were extracted by one reviewer and checked by another reviewer. Quality of the included studies was evaluated using the Newcastle-Ottawa scale. Sensitivity analysis was performed by removing each study at a time. Review Manager (RevMan)version 5.3 was used for the statistical analysis.

Results: Only six articles met the inclusion criteria with 449889 patients with IBD and 9138355 patients with non-IBD. The study was conducted in US (n= 2), Denmark (n= 1), Sweden (n= 1), Taiwan (n= 1), and Korea (n= 1). Included studies were of high quality. Outcomes (PD cases) were identified using the international classification of diseases code 332 in the majority of the included studies. IBD was found to be significantly associated with an increased risk of PD with a relative risk (RR) of 1.32 (95% CI: 1.06 – 1.64), p = 0.01 [figure 1]. Similarly, significantly higher PD risk was found among patients with ulcerative colitis with RR of 1.38 (95% CI: 1.18 – 1.58), p = <0.05, while the risk of PD was non-significant with Crohn’s disease. Subgroup analysis revealed significantly higher PD risk on the basis of sex, and age groups (>65 years and ≤65 years old).

Conclusions: This meta-analysis suggests an increased risk of PD in patients with IBD as well as ulcerative colitis. However, well-designed future studies are warranted to make the evidence more robust.