(P-142) Non-persistence with Statins in Diabetic and Non-diabetic Patients with Transient Ischemic Attack

Background: Secondary prevention of transient ischemic attack (TIA) includes administration of statins.

Objectives: The aims of our study were: a) analysis of non-persistence with statins in diabetic and non-diabetic patients after TIA, and b) identification of patient-related characteristics associated with non-persistence.

Methods: The database of the General Health Insurance Company represented a source of data for our study. The cohort included 797 TIA patients (63.2% of them women), in whom statin treatment was initiated between 1 January 2010 and 31 December 2010. From the index date, patients were followed for three years. Patients with a treatment gap of six months without any statin prescription were classified as non-persistent. The Cox proportional hazards model was used to identify patient-related characteristics associated with non-persistence. All analyses were performed in the whole study sample (n=797) and separately in subgroups of diabetic (n=244) and non-diabetic (n=553) patients.

Results: At the end of the 3-year follow-up period, 441 (55.3%) patients of the whole sample (n=797) were non-persistent with statin treatment. In the analysed subgroups, 109 (44.7%) of 244 diabetic patients and 332 (60.0%) of 553 non-diabetic subjects were non-persistent with statins. Diabetes mellitus was associated with decreased patient´s likelihood of non-persistence.

Conclusions: According to the results of our study, TIA patients with diabetes mellitus were more persistent with statin treatment than those without this condition.